While on vacation in Mexico, Chloe (Barrymore), a pampered Beverly Hills chihuahua, finds herself lost and in need of assistance in order to get back home. Coming to Chloe's aid is a a macho Chihuahua named Papi (Lopez), a spirit guide (Hayek) who endeavors to help Chloe discover her true heritage.

Two strangers (LaBeouf and Monaghan) become the pawns of a mysterious woman they have never met, but who seems to know their every move. Realizing they are being used to further her plot for a political assassination, they must work together to outwit the woman before she has them killed.

Nick (Cera) asks Nora (Dennings) to pretend to be his girlfriend for 5 minutes so he won't have to feel as awkward around his ex-g.f., who just walked into the club where Nick's band is playing ... with a new guy. But when the fake couple decides to kiss, sparkage occurs, leading to a first date which seems to span all of New York City.

A doctor (Gere) who is traveling to see his estranged son sparks with an unhappily married woman (Lane) at a North Carolina inn

A pair of lawmen (Harris and Mortensen) out to save a Western town from a rancher's tyrannical reign find their bond, and their mission, tested by the arrival of a double-dealing widow (Zellweger).